United States Patent | 5,248,498 |
Neumann, et. al. | Sept. 28, 1993 |
Inventors: | Neumann; William L. (Grover, MO); Cacheris; William P. (Florissant, MO). |
Assignee: | Mallinckrodt Medical, Inc. (St. Louis, MO). |
Appl. No.: | 746,836 |
Filed: | Aug. 19, 1991 |
Intl. Cl.: | G01N 24/08; C07C 19/08; C01F 17/00; C01B 31/02; |
U.S. Cl.: | 424/9.; 534/15.; |
Field of Search: | 9;1.1 |
4,647,447 | Mar., 1987 | Gries et al. | 424/ 9 |
5,114,477 | May, 1992 | Mort et al. | 106/ 20 |
5,132,105 | Jul., 1992 | Remo | 423/446 |
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Methods and compositions are disclosed for enhancing magnetic resonance imaging and spectroscopy which utilize derivatives of the even-numbered carbon clusters, known as "fullerenes." Perfluorinated carbon clusters of the formula C(n) F(m), wherein n is in the range from 30-100 and m<=n, may be used for fluorine-19 imaging. Incorporating paramagnetic metal species into the carbon cluster cage improves fluorine and proton imaging.