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United States Patent 5,248,498
Neumann, et. al.Sept. 28, 1993

Fullerene compositions for magnetic resonance spectroscopy and imaging

Inventors: Neumann; William L. (Grover, MO); Cacheris; William P. (Florissant, MO).
Assignee: Mallinckrodt Medical, Inc. (St. Louis, MO).
Appl. No.: 746,836
Filed: Aug. 19, 1991

Intl. Cl.:G01N 24/08; C07C 19/08; C01F 17/00; C01B 31/02;
U.S. Cl.:424/9.; 534/15.;
Field of Search:9;1.1

References Cited

U.S. Patent Documents
4,647,447Mar., 1987Gries et al. 424/ 9
5,114,477May, 1992Mort et al. 106/ 20
5,132,105Jul., 1992Remo 423/446

Other References

Primary Examiner: Robinson; Allen J.
Assistant Examiner: Hollinden; Gary E.


Methods and compositions are disclosed for enhancing magnetic resonance imaging and spectroscopy which utilize derivatives of the even-numbered carbon clusters, known as "fullerenes." Perfluorinated carbon clusters of the formula C(n) F(m), wherein n is in the range from 30-100 and m<=n, may be used for fluorine-19 imaging. Incorporating paramagnetic metal species into the carbon cluster cage improves fluorine and proton imaging.

17 Claims, 2 Drawing Figures

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